Composition and Formula
Urea, also known as carbamide, is an organic compound with
chemical formula CO(NH2)2. This amide has two NH2 groups
joined by a carbonyl (C=O) functional group.
Urea serves an important role in the metabolism of nitrogen
containing compounds by animals and is the main nitrogen
containing substance in the urine of mammals.
It is a
colour less, odourless solid, highly soluble in water, and
practically non toxic (LD50 is 15 g/kg for rats). Dissolved in water, it
is neither acidic nor alkaline. The body uses it in many processes,
most notably nitrogen excretion.
The liver forms it by combining two ammonia molecules (NH3)
with a carbon dioxide (CO2) molecule in the urea cycle. Urea is
widely used in fertilizers as a source of nitrogen (N) and is an
important raw material for the chemical industry.
Friedrich
Wöhler’s discovery, in 1828, that Urea can be produced
from inorganic starting materials, was an important conceptual
milestone in chemistry. It showed, for the first time, that a
substance, previously known only as a by product of life, could be
synthesized in the laboratory, without biological starting materials,
thereby contradicting the widely held doctrine vitalism, which
stated that only living things could produce the chemicals of life.