Model NO. | ivermectin | Usage | Laboratory Reagents, Analytical Reagents |
Source | Dry Powder | Habit Appellation | Chemical Medicine |
Application | Industry, Scientific Research | Property | Medical Grade |
Transport Package | Kg/Bag | Specification | 1kg |
Trademark | Star-Selection | Origin | Huanggang |
HS Code | 000000 | Production Capacity | 10000000vials/Year |
Product Name | Ivermectin |
CAS | 70288-86-7 |
Molecular formula | C48H74O14 |
Molecular weight | 875.09300 |
Grade | Pharmaceutical Grade |
Color | White powder |
Purity | 99% |
Shelf life | 2 years |
The
Introductction of
Ivermectin:
Ivermectin is widely used in cattle, sheep,
horses, pigs, gastrointestinal nematodes, lung nematodes
and parasitic arthropod,
canine intestinal nematodes, ear
mites, scabies mites, silk worm and microfilariae,
gastrointestinal nematodes and external parasites and
poultry. This product belong to the broad-spectrum
resistant parasites.
Ivermectin for a variety of most
of the life cycle of nematodes (but not all nematodes)
role; For dish tail filarial microfilariae
effectively, but for adult
worms; For only in intestinal fecal round worms are also
effective.
Ivermectin has the selective
inhibitory effect, with no spinal nerve cells and muscle
cells in the animal glutamic acid ion channels of the valve
is the high binding affinity, leading to the proliferation
of the chloride ion permeability of cell membrane, cause
nerve cells or muscle cells hyperpolarization, parasites
paralysis or
death.
The Application & Function of Ivermectin:
1. Ivermectin is the derivatives of
abamectin. Ivermectin belongs to semisynthetic
broad-spectrum resistant parasites.
2. Ivermectin has effect for
most of the various life cycle nematodes.
3. Ivermectin has effect for the
microfilaria of onchocerca volvulus,but it does not has
effect for the adult onchocerca volvulus.
4. Ivermectin has effect for
dung round worms that is only stay in intestinal
tract.
5. Ivermectin has selective
inhibition.
6. Ivermectin can not go through
the blood brain barrier of
humanbeings.
In veterinary medicine ivermectin powder is
used against many intestinal worms (but not tapeworms),
most mites, and some lice. Despite this, it is not
effective for eliminating ticks, flies, flukes, or fleas.
It is effective against larval heartworms, but not against
adult heartworms, though it may shorten their lives. The
dose of the medicine must be very accurately measured as it
is very toxic in over-dosage.
It is sometimes administered in combination
with other medications to treat a broad spectrum of animal
parasites. Some dog breeds (especially the Rough Collie,
the Smooth Collie, the Shetland Sheepdog, and the
Australian Shepherd), though, have a high incidence of a
certain mutation within the MDR1 gene (coding for
P-glycoprotein); affected animals are particularly
sensitive to the toxic effects of
ivermectin.
Clinical evidence suggests kittens are
susceptible to ivermectin toxicity. A 0.01% ivermectin
topical preparation for treating ear mites in cats
(Acarexx) is available.
Ivermectin is sometimes used as an acaricide
in reptiles, both by injection and as a diluted spray.
While this works well in some cases, care must be taken, as
several species of reptiles are very sensitive to
ivermectin. Use in turtles is particularly
contraindicated.
Other Name of Ivermectin: IVERMECTINHCL;IvermectinEP2000;IVERMECTINNOTLESSTHAN93.0%OF22,23-DIHY-DROAVERMECTINB1A,ANDNOTLESSTHAN97.0%OF22,23-DIChemicalbookHY-DROAVERMECTINB1(B1A+B1B);IVERMECTINEP(CRMSTANDARD);IVERMECTINUSP(CRMSTANDARD);IvermectineEp2000;IVOMEC;IVERMECTIN
Tests | Specification | Results | |
Appearance | White or yellowish-white crystalline powder, slightly hygroscopic. | Yellowish-white crystalline powder, slight hygroscopic. | |
Solubility | Practically insoluble in water, soluble in alcohol. | Qualified | |
Identification | IR | Corresponds to that of CRS standard | Qualified |
HPLC | The retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparation | Qualified | |
Appearance of solution | Clear and not more intensely colored than BY? | Clear | |
Specific optical rotation (anhydrous and solvent-free substance), ° | -20--17 | -17.9 | |
Related substances (%) | Individual impurity(RRT 1.3-1.5)≤2.5 | I-l:<0.05 K:2.1 | |
Any other impurity ≤ 1 |
C:0.06
A:0.57 J:0.14 H:0.39 D:<0.05 F:<0.05 E:0.36 1-2:0.19 |
||
Total ≤5 | 3.8 | ||
Disregard limit: 0.05 | |||
Ethanol and Formamide (%) | Ethanol ≤5.0 | 3.9 | |
Formamide≤3.0 | 2.5 | ||
Catalyst (ug/g) | ≤1 | <1 | |
Water (%) | ≤1.0 | 0.26 | |
Sulphated ash (%) | ≤0.1 | 0.07 | |
Heavy Metal (%) | ≤0.002 | <0.002 | |
Assay (%) (HPLC, on dry basis) | H2Bla/(H2Bla +H2Blb)≥90.0 | 97.7 | |
95.0≤H2Bla +H2Blb≤ 102.0 | 96.7 | ||
Conclusion | Complies with the requirements of EP10.0 |